Modern digital pathology department has evolved to produce a whole-slide image data at petabyte scale, a treasure chest unprecedented for a medical machine learning tasks. Unfortunately, most of the digital slide is not described at the level of the image, hindering the large-scale application of supervised learning. Users labeling is expensive, requires a pathologist with decades of training and responsibility exceptional clinical care.

This problem is exacerbated by the United States Food and Drug Administration ruling that the primary diagnosis must come from the slide glass rather than digital images. We present a framework of end-to-end first to solve this problem, collect the explanation nonintrusive during routine clinical pathologist working this: commodities (i) 3D-print a special microscope camera mounts are used for video recording Slide- glass-based clinical diagnostic process ; (Ii) after a routine scan the whole slide, registered video frames to digital slide; (Iii) the estimated time of motion and observations to produce spatial and temporal saliency map of the entire slide.

Demonstrating the utility of this explanation, we train a neural network convolutional that detects elevated area relevant diagnosis, then report the accuracy of 85.15% in the bladder and in the prostate 91.40%, with 75.00% accuracy during training but predicting prostate bladder, although different pathologists examine a different network. When the train in one patient but other test, AUROC in bladder was 0.79 ± 0.11 and 0.96 ± 0:04 prostate.

Cost-effective and automated acquisition of the whole slide images are obstacles to wide-scale deployment of digital pathology. In this article, the calculation of which is coupled approaches to the development of the microscope slide scanner automatically presented. Realization of the prototype device built using inexpensive optical components off-the-shelf and detailed motors.

Application of advanced prototypes for clinical diagnostic tests is shown by producing good quality digital images of malaria infected blood smears. Furthermore, the slide images obtained were processed to identify and count the number of red blood cells infected with malaria and thus to estimate the level of quantitative parasitaemia. The prototype presented will enable cost-effective deployment of slide-based testing cyto-diagnostic in endemic areas.

Boveri Research Zoological Station in Naples: The rediscovery of the original microscope slides at the University of Würzburg.

Eric Davidson wrote about Theodor Boveri: “From his own research, and perhaps most importantly, his interpretation of the public, from the underlying paradigm of modern questions to base genome of embryogenesis” (Davidson, 1985).

As luck would have it, “primary data” from the experimental work Boveri, the microscope slides prepared by him and his wife Marcella during several stays at the Zoological Station in Naples (1901-1902, 1911-1912 and 1914), survived at the University of Würzburg. More than 600 slides there and despite their age they are in surprisingly good condition.

Microscope Slide Boxes,100-Place, Red
LC7004-100	GenDepot	100/CS	EUR 967.2

Microscope Slide Boxes,25-Place, Red
LC7009-001	GenDepot	EA	EUR 79.2

Microscope Slide Boxes,25-Place, Red
LC7009-010	GenDepot	10/PK	EUR 148.8

Microscope Slide Boxes,25-Place, Red
LC7009-100	GenDepot	100/CS	EUR 684

Microscope Slide Boxes,100-Place, Blue
LC7002-001	GenDepot	Ea	EUR 84

Microscope Slide Boxes,100-Place, Blue
LC7002-010	GenDepot	10/PK	EUR 181.2

Microscope Slide Boxes,100-Place, Blue
LC7002-100	GenDepot	100/CS	EUR 967.2

Microscope Slide Boxes,25-Place, Blue
LC7007-001	GenDepot	EA	EUR 79.2

Microscope Slide Boxes,25-Place, Blue
LC7007-010	GenDepot	10/PK	EUR 148.8

Microscope Slide Boxes,25-Place, Blue
LC7007-100	GenDepot	100/CS	EUR 684

Microscope Slide Boxes,100-Place, Green
LC7003-001	GenDepot	Ea	EUR 84

Microscope Slide Boxes,100-Place, Green
LC7003-010	GenDepot	10/PK	EUR 181.2

Microscope Slide Boxes,100-Place, Green
LC7003-100	GenDepot	100/CS	EUR 967.2

Microscope Slide Boxes,100-Place, White
LC7006-001	GenDepot	Ea	EUR 84

Microscope Slide Boxes,100-Place, White
LC7006-010	GenDepot	10/PK	EUR 181.2

Microscope Slide Boxes,100-Place, White
LC7006-100	GenDepot	100/CS	EUR 967.2

Microscope Slide Boxes,25-Place, Green
LC7008-001	GenDepot	EA	EUR 79.2

Microscope Slide Boxes,25-Place, Green
LC7008-010	GenDepot	10/PK	EUR 148.8

Microscope Slide Boxes,25-Place, Green
LC7008-100	GenDepot	100/CS	EUR 684

Microscope Slide Boxes,25-Place, White
LC7011-001	GenDepot	EA	EUR 79.2

Microscope Slide Boxes,25-Place, White
LC7011-010	GenDepot	10/PK	EUR 148.8

Microscope Slide Boxes,25-Place, White
LC7011-100	GenDepot	100/CS	EUR 684

Microscope Slide Boxes,100-Place, Yellow
LC7005-001	GenDepot	Ea	EUR 84

Microscope Slide Boxes,100-Place, Yellow
LC7005-010	GenDepot	10/PK	EUR 181.2

Microscope Slide Boxes,100-Place, Yellow
LC7005-100	GenDepot	100/CS	EUR 967.2

Microscope Slide Boxes,25-Place, Yellow
LC7010-001	GenDepot	EA	EUR 79.2

Microscope Slide Boxes,25-Place, Yellow
LC7010-010	GenDepot	10/PK	EUR 148.8

Microscope Slide Boxes,25-Place, Yellow
LC7010-100	GenDepot	100/CS	EUR 684

Gelatin-coated microscope slides (75 x 25 mm)
PO101	FD Neurotechnologies	100 slides	EUR 236.4

Premium Microscope Slide Box 50-Place Cork Red
MIC4216	Scientific Laboratory Supplies	EACH	EUR 21.46

Plastic box for 100 microscope slides (red colour)
DD37503	Scientific Laboratory Supplies	EACH	EUR 38.4

Premium Microscope Slide Box 50-Place Cork Blue
MIC4214	Scientific Laboratory Supplies	EACH	EUR 26.52

Plastic box for 100 microscope slides (blue colour)
DD37501	Scientific Laboratory Supplies	EACH	EUR 38.4

Microscope slide dispenser for box of 72 standard 25 x 75mm slides
M7100-SD	MTC Bio	1/pack	EUR 83.89
Description: Microscope slide dispenser

Box for 25 microscope slides purple colour
DD49719	Scientific Laboratory Supplies	EACH	EUR 19.2

Box for 25 microscope slides orange colour
DD49720	Scientific Laboratory Supplies	EACH	EUR 19.2

Box for 25 microscope slides turquoise colour
DD49721	Scientific Laboratory Supplies	EACH	EUR 19.2

Polystyrene box for 100 microscope slides blue colour
DD139537	Scientific Laboratory Supplies	EACH	EUR 22.8

Polystyrene box for 100 microscope slides green colour
DD139538	Scientific Laboratory Supplies	EACH	EUR 22.8

Gelatin-coated microscope slides (75 x 50 mm)
PO105	FD Neurotechnologies	100 slides	EUR 420

2 Place Microscope Slide Mailer PP Natural
MIC3172	Scientific Laboratory Supplies	PK25	EUR 46.92

Plastic box for 100 microscope slides (assorted colours) cork bottom
DD10197	Scientific Laboratory Supplies	PK5	EUR 87.6

Plastic box for 50 microscope slides (blue colour)
DD37507	Scientific Laboratory Supplies	EACH	EUR 32.4

Microscope Slide Box 25 ULT safe
MIC4092	Scientific Laboratory Supplies	EACH	EUR 19.37

2 Place Microscope Slide Mailer PP Assorted Colours
MIC3170	Scientific Laboratory Supplies	PK25	EUR 48

TruBond 380 Adhesive Microscope Slides, 100 pcs/box
IW-T380	IHC World	-	EUR 45

Microscope Slides, Plain
07441-1	Polysciences Europe GmbH	1box	EUR 50

Microscope Slide Box True North
MIC4090	Scientific Laboratory Supplies	EACH	EUR 47.52

Microscope Slide Storage Box, Plastic small box
16603-1	Polysciences Europe GmbH	1bag	EUR 28

Microscope Slide Storage Box, Plastic large box
16604-1	Polysciences Europe GmbH	1each	EUR 54

Microscope Slides, Micropure
22245-20	Polysciences Europe GmbH	1box	EUR 380

Microscope Slides, Micropure
22245-1	Polysciences Europe GmbH	1box	EUR 32

Cardboard tray for 20 microscope slides
DD65205	Scientific Laboratory Supplies	EACH	EUR 19.2

Premium Plain Glass Microscope Slides, 144 /pk, 1 mm thickness, 25 mm wide by 73 mm long
M-ACC-GSL9	MiTeGen	200 TIPS	EUR 65
Description: Premium Plain Glass Microscope Slides, 144 /pk, 1 mm thickness, 25 mm wide by 73 mm long

Microscope Slides Plain 1.0mm 76x52mm
MIC2156	Scientific Laboratory Supplies	PK50	EUR 19.2

Quartz Microscope Slide, 1"x2" (25.4 x 50.8 mm) x 0.5 mm Thin
24962-1	Polysciences Europe GmbH	1EA	EUR 217

Quartz Microscope Slide, 1"x3" (25.4 x 76.2 mm) x 0.5 mm Thin
24963-1	Polysciences Europe GmbH	1EA	EUR 192

Quartz Microscope Slide, 1"x1" (25.4 x 25.4 mm) x 1 mm Thick
24957-1	Polysciences Europe GmbH	1EA	EUR 58

Vinyl microscope slides RINZL
DD52951	Scientific Laboratory Supplies	PK144	EUR 24.62

Microscope Slides Plain 1.2-1.5mm 76x26mm
MIC2154	Scientific Laboratory Supplies	PK50	EUR 4.08

Super Frosted Microscope Slides
21912-1	Polysciences Europe GmbH	1box	EUR 60

Polysine Coated Microscope Slides
26414-1	Polysciences Europe GmbH	1box	EUR 82

Polysine Coated Microscope Slides
26414-20	Polysciences Europe GmbH	20box	EUR 585

Microscope Slides, Immunofluorescence
18357-1	Polysciences Europe GmbH	1box	EUR 168

Superfrost® Plus microscope slides
PO103	FD Neurotechnologies	box (72 slides)	EUR 123.6

Tissue Tack (+ Charged) Microscope Slides
24216-1	Polysciences Europe GmbH	1box	EUR 55

Tissue Tack (+ Charged) Microscope Slides
24216-20	Polysciences Europe GmbH	20box	EUR 720

Proteinase-resistant microscope slides
PO102	FD Neurotechnologies	100 slides	EUR 236.4

Microscope Slide Coverslips, Plastic
16601-1	Polysciences Europe GmbH	1box	EUR 148

Microscope Slide Holder Block
24764-1	Polysciences Europe GmbH	1each	EUR 148

Microscope Slide Mailing Tubes
23998-10	Polysciences Europe GmbH	10pkg	EUR 40

Microscope slides, positive charged, 45° corners, frosted on one end, 25 x 75mm
M7100-45	MTC Bio	72/pack	EUR 75.4
Description: Microscope slides positive charged

Microscope slides, positive charged, 90° corners, frosted on one end, 25 x 75mm
M7100-90	MTC Bio	72/pack	EUR 75.4
Description: Microscope slides positive charged

Microscope Slide Coverslips, Glass, 22mm x 30mm
23999-1	Polysciences Europe GmbH	1oz	EUR 40

Microscope Slide Coverslips, Glass, 24mm x 40mm
24070-1	Polysciences Europe GmbH	1oz	EUR 40

Microscope Slide Coverslips, Glass, 24mm x 50mm
24071-1	Polysciences Europe GmbH	1oz	EUR 41

Microscope Slide Coverslips, Glass, 24mm x 60mm
24072-1	Polysciences Europe GmbH	1oz	EUR 53

Microscope Slide Coverslips, Glass, 22mm x 22mm
21913-1	Polysciences Europe GmbH	1oz	EUR 40

TruBond 380 Adhesive Microscope Slides, 1000 pcs/case
IW-T380C	IHC World	-	EUR 385

Microscope Slide Storage Cabinet
22352-1	Polysciences Europe GmbH	1each	EUR 278

Microscope Slide Polysine 75x25x1mm
MIC3050	Scientific Laboratory Supplies	PK72	EUR 43.22

BRAND(TM) MICROSCOPE SLIDE CUT EDGES
BR474701-2500EA	Scientific Laboratory Supplies	PK2500	EUR 218.4

Microscope Slide Holder, Peel-A-Way
19801A-1	Polysciences Europe GmbH	1Box	EUR 56

Slide Storage Box for Large Slides 75x50x1mm, 25-place, each
97-0625	IHC World	-	EUR 15

Wooden Slide Storage Box for Large Slides 75x38x1mm, 100-place
IW-2005	IHC World	-	EUR 45

Wooden Slide Storage Box for Large Slides 75x50x1mm, 100-place
IW-2006	IHC World	-	EUR 38

Microscope Slide Storage Cabinet Base Unit
22353-1	Polysciences Europe GmbH	1each	EUR 397

Microscope Slides 26X76mm Ground Edges Double Frosted 45° Angle -Silver-
VBS656	Scientific Laboratory Supplies	PK2500	EUR 262.8

SLIDE BOX; 100 PLACE; BLUE
HS15991A	Scientific Laboratory Supplies	EACH	EUR 20.52

AutoFrost Enhanced IHC Microscope Slides, Clipped corner, White, 3000pcs/case
EMP00W3	IHC World	-	EUR 1250

Economy Slide box 100 Place RED
MIC3588	Scientific Laboratory Supplies	EACH	EUR 22.1

Economy Slide box 100 Place BLUE
MIC3586	Scientific Laboratory Supplies	EACH	EUR 22.1

Economy Slide box 100 Place WHITE
MIC3590	Scientific Laboratory Supplies	EACH	EUR 18.4

Economy Slide box 25 Place RED
MIC3582	Scientific Laboratory Supplies	EACH	EUR 14.63

Economy Slide box 25 Place BLUE
MIC3580	Scientific Laboratory Supplies	EACH	EUR 14.63

Economy Slide box 25 Place WHITE
MIC3584	Scientific Laboratory Supplies	EACH	EUR 15.84

Slide Box White for 25 Slides
MIC4000	Scientific Laboratory Supplies	EACH	EUR 12.08

PREMIUM SLIDE BOX 100 PLACE CORK LINI
HS15994G	Scientific Laboratory Supplies	EACH	EUR 32.4

PREMIUM SLIDE BOX 25 PLACE FOAM LININ
HS15989R	Scientific Laboratory Supplies	EACH	EUR 20.4

25-Place Slide Storage Box, red, each
97-0028	IHC World	-	EUR 5.8

100-Place Slide Storage Box, red, each
97-0128	IHC World	-	EUR 9.8

25-Place Slide Storage Box, blue, each
97-0026	IHC World	-	EUR 5.8

100-Place Slide Storage Box, blue, each
97-0126	IHC World	-	EUR 9.8

25-Place Slide Storage Box, white, each
97-0025	IHC World	-	EUR 5.8

25-Place Slide Storage Box, green, each
97-0027	IHC World	-	EUR 5.8

100-Place Slide Storage Box, white, each
97-0125	IHC World	-	EUR 9.8

100-Place Slide Storage Box, green, each
97-0127	IHC World	-	EUR 9.8

25-Place Slide Storage Box, yellow, each
97-0029	IHC World	-	EUR 5.8

Slide Box Red 100 Slides
MIC3554	Scientific Laboratory Supplies	EACH	EUR 41.04

100-Place Slide Storage Box, yellow, each
97-0129	IHC World	-	EUR 9.8

Slide Box Blue 100 Slides
MIC3550	Scientific Laboratory Supplies	EACH	EUR 25.44

Slide Box Grey 100 Slides
MIC3560	Scientific Laboratory Supplies	EACH	EUR 33.36

Slide Box Green 100 Slides
MIC3552	Scientific Laboratory Supplies	EACH	EUR 26.88

Slide Box White 100 Slides
MIC3558	Scientific Laboratory Supplies	EACH	EUR 36.12

Slide Box Red 25 Slides
MIC3566	Scientific Laboratory Supplies	EACH	EUR 22.8

Slide Box Yellow 100 Slides
MIC3556	Scientific Laboratory Supplies	EACH	EUR 42.24

Slide Box Blue 25 Slides
MIC3562	Scientific Laboratory Supplies	EACH	EUR 23.75

Slide Box Green 25 Slides
MIC3564	Scientific Laboratory Supplies	EACH	EUR 23.75

Slide Box White 25 Slides
MIC3570	Scientific Laboratory Supplies	EACH	EUR 23.75

Slide Box Polystyrene 100 Slides
MIC4012	Scientific Laboratory Supplies	EACH	EUR 30.24

Slide Box Storage Rack 15 Place
MIC3180	Scientific Laboratory Supplies	EACH	EUR 644.4

Slide Box White for 50 Slides
MIC4004	Scientific Laboratory Supplies	EACH	EUR 14.4

5-place Plastic Slide Mailer, 100 pcs/pack
MSL-15	IHC World	-	EUR 46.8

Slide Box 25 Slide Polystyrene
MIC4066	Scientific Laboratory Supplies	EACH	EUR 14.36

30-Place cardboard slide tray
MIC4201	Scientific Laboratory Supplies	EACH	EUR 40.8

Microscope Cover Slips No. 1.5 16mm
MIC2182	Scientific Laboratory Supplies	PK100	EUR 10.8

Normal Human Placenta (5 slides/pack, single section/slide)
S-HuFPT080	TissueArray	1 unit	EUR 95

Cynomolgus Monkey:Placenta (5 slides/pack, single section/slide)
S-CyFPT202	TissueArray	1 unit	EUR 95

Human Urogenital Tissue Slide (Placenta Benign) (5 slides/pk)
HTS-11913	Alpha Diagnostics	1 pk	EUR 343.2

Microscope Cover Slips No. 0 18x18mm
MIC2158	Scientific Laboratory Supplies	PK100	EUR 3.6

Microscope Cover Slips No. 0 22x22mm
MIC2160	Scientific Laboratory Supplies	PK100	EUR 3.6

Microscope Cover Slips No. 1 18x18mm
MIC2162	Scientific Laboratory Supplies	PK100	EUR 2.4

Microscope Cover Slips No. 1 22x22mm
MIC2164	Scientific Laboratory Supplies	PK100	EUR 3.6

Microscope Cover Slips No. 1.5 18x18mm
MIC2166	Scientific Laboratory Supplies	PK100	EUR 2.4

Microscope Cover Slips No. 1.5 22x22mm
MIC2168	Scientific Laboratory Supplies	PK100	EUR 3.6

Microscope Cover Slips No.1.5 22x26mm
MIC2170	Scientific Laboratory Supplies	PK100	EUR 4.8

Microscope Cover Slips No. 1.5 22x32mm
MIC2172	Scientific Laboratory Supplies	PK100	EUR 4.8

Microscope Cover Slips No. 1.5 22x40mm
MIC2174	Scientific Laboratory Supplies	PK100	EUR 6

Microscope Cover Slips No. 2 18x18mm
MIC2176	Scientific Laboratory Supplies	PK100	EUR 3.6

Microscope Cover Slips No. 2 22x22mm
MIC2178	Scientific Laboratory Supplies	PK100	EUR 4.8

Slide Tray Singles x 20 Slides
MIC4200	Scientific Laboratory Supplies	EACH	EUR 18.13

Slide dryer attachment for 3 slides
B1000-03	Benchmark Scientific	1 PC	EUR 137.3

Microscope Cover Slips No. 0 19mm dia
MIC2180	Scientific Laboratory Supplies	PK100	EUR 12

Normal Human Placenta (single section per slide) (5 slides/pack)
HuFPT080	TissueArray	5 slides	EUR 150

Cynomolgus Monkey:Placenta (single section per slide) (5 slides/pack)
CyFPT202	TissueArray	5 slides	EUR 150

20-place Slide Folder, cardboard, each
MSL-20	IHC World	-	EUR 12.5

20-place Slide Folder, Blue, plastic, each
M750-20B	IHC World	-	EUR 14.5

20-place Slide Folder, Gray, plastic, each
M750-20GY	IHC World	-	EUR 14.5

Slide Rack (for 24 Slides), Stainless Steel
IMS003	ScyTek Laboratories	1 ea.	EUR 115.2

1-Place Cardboard Slide Holders Cardboard
MIC4210	Scientific Laboratory Supplies	PK25	EUR 33.36

2-Place Cardboard Slide Holders Cardboard
MIC4212	Scientific Laboratory Supplies	PK36	EUR 70.8

20-place Slide Folder, Green, plastic, each
M750-20G	IHC World	-	EUR 14.5

20-place Slide Folder, White, plastic, each
M750-20W	IHC World	-	EUR 14.5

20-place Slide Folder, Yellow, plastic, each
M750-20Y	IHC World	-	EUR 14.5

2-place Cardboard Slide Mailer, 10 pcs/pack
41-4002	IHC World	-	EUR 5.8

Slide Holder Stainless Steel Rack (for 30 Slides)
IMS005	ScyTek Laboratories	1 ea.	EUR 96

Placenta Tissue Slides, Normal Rat Paraffin Sections, 5 slides/pack
TS-R5409	IHC World	-	EUR 145

20-Place Cardboard Slide Mailer w/Index Sheet
LC7001-010	GenDepot	10/Pk	EUR 181.2

20-Place Cardboard Slide Mailer w/Index Sheet
LC7001-040	GenDepot	40/CS	EUR 408

Placenta Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5207	IHC World	-	EUR 145

Plastic cell counting slides Kovas Slide
DD50126	Scientific Laboratory Supplies	EACH	EUR 294

TOMO Slides 1 Box
TOMO100	ScyTek Laboratories	100 Slides	EUR 108

Stereo Microscope Trinocular
MIC1590	Scientific Laboratory Supplies	EACH	EUR 1274.27

Microscope Binoc MAGNUM-B planachrom obj
MIC0105	Scientific Laboratory Supplies	EACH	EUR 2008.8

Slide labeled and dated in handwriting Boveri and thus can be assigned to publish the experimental work at sea urchin development. Results Boveri allowed to reveal the role of the cell nucleus and chromosomes in the development and heritage. Here, I present an overview of the slides in the context Boveri work together with images of selected specimens taken from the original slide. It is planned to check the slide in more detail, taking high-resolution pictures a series of specimens of significant focus and make them available online.