Modern digital pathology department has evolved to produce a whole-slide image data at petabyte scale, a treasure chest unprecedented for a medical machine learning tasks. Unfortunately, most of the digital slide is not described at the level of the image, hindering the large-scale application of supervised learning. Users labeling is expensive, requires a pathologist with decades of training and responsibility exceptional clinical care.

This problem is exacerbated by the United States Food and Drug Administration ruling that the primary diagnosis must come from the slide glass rather than digital images. We present a framework of end-to-end first to solve this problem, collect the explanation nonintrusive during routine clinical pathologist working this: commodities (i) 3D-print a special microscope camera mounts are used for video recording Slide- glass-based clinical diagnostic process ; (Ii) after a routine scan the whole slide, registered video frames to digital slide; (Iii) the estimated time of motion and observations to produce spatial and temporal saliency map of the entire slide.

Demonstrating the utility of this explanation, we train a neural network convolutional that detects elevated area relevant diagnosis, then report the accuracy of 85.15% in the bladder and in the prostate 91.40%, with 75.00% accuracy during training but predicting prostate bladder, although different pathologists examine a different network. When the train in one patient but other test, AUROC in bladder was 0.79 ± 0.11 and 0.96 ± 0:04 prostate.

Cost-effective and automated acquisition of the whole slide images are obstacles to wide-scale deployment of digital pathology. In this article, the calculation of which is coupled approaches to the development of the microscope slide scanner automatically presented. Realization of the prototype device built using inexpensive optical components off-the-shelf and detailed motors.

Application of advanced prototypes for clinical diagnostic tests is shown by producing good quality digital images of malaria infected blood smears. Furthermore, the slide images obtained were processed to identify and count the number of red blood cells infected with malaria and thus to estimate the level of quantitative parasitaemia. The prototype presented will enable cost-effective deployment of slide-based testing cyto-diagnostic in endemic areas.

Boveri Research Zoological Station in Naples: The rediscovery of the original microscope slides at the University of Würzburg.

Eric Davidson wrote about Theodor Boveri: “From his own research, and perhaps most importantly, his interpretation of the public, from the underlying paradigm of modern questions to base genome of embryogenesis” (Davidson, 1985).

As luck would have it, “primary data” from the experimental work Boveri, the microscope slides prepared by him and his wife Marcella during several stays at the Zoological Station in Naples (1901-1902, 1911-1912 and 1914), survived at the University of Würzburg. More than 600 slides there and despite their age they are in surprisingly good condition.

Microscope Slide Boxes,100-Place, Red
LC7004-100	GenDepot	100/CS	EUR 806

Microscope Slide Boxes,100-Place, Yellow
LC7005-100	GenDepot	100/CS	EUR 806

Microscope Slide Boxes,100-Place, White
LC7006-100	GenDepot	100/CS	EUR 806

Microscope Slide Boxes,25-Place, Blue
LC7007-100	GenDepot	100/CS	EUR 570

Microscope Slide Boxes,25-Place, Green
LC7008-100	GenDepot	100/CS	EUR 570

Microscope Slide Boxes,25-Place, Red
LC7009-100	GenDepot	100/CS	EUR 570

Microscope Slide Boxes,25-Place, Yellow
LC7010-100	GenDepot	100/CS	EUR 570

Microscope Slide Boxes,25-Place, White
LC7011-100	GenDepot	100/CS	EUR 570

Microscope Slide Boxes,100-Place, Blue
LC7002-001	GenDepot	Ea	EUR 70

Microscope Slide Boxes,100-Place, Blue
LC7002-010	GenDepot	10/PK	EUR 151

Microscope Slide Boxes,100-Place, Green
LC7003-001	GenDepot	Ea	EUR 70

Microscope Slide Boxes,100-Place, Green
LC7003-010	GenDepot	10/PK	EUR 151

Microscope Slide Boxes,100-Place, Red
LC7004-001	GenDepot	Ea	EUR 70

Microscope Slide Boxes,100-Place, Red
LC7004-010	GenDepot	10/PK	EUR 151

Microscope Slide Boxes,100-Place, Yellow
LC7005-001	GenDepot	Ea	EUR 70

Microscope Slide Boxes,100-Place, Yellow
LC7005-010	GenDepot	10/PK	EUR 151

Microscope Slide Boxes,100-Place, White
LC7006-001	GenDepot	Ea	EUR 70

Microscope Slide Boxes,100-Place, White
LC7006-010	GenDepot	10/PK	EUR 151

Gelatin-coated microscope slides (75 x 50 mm)
PO105	FD Neurotechnologies	100 slides	EUR 350

Microscope Slide Boxes,25-Place, Blue
LC7007-001	GenDepot	EA	EUR 66

Microscope Slide Boxes,25-Place, Blue
LC7007-010	GenDepot	10/PK	EUR 124

Microscope Slide Boxes,25-Place, Green
LC7008-001	GenDepot	EA	EUR 66

Microscope Slide Boxes,25-Place, Green
LC7008-010	GenDepot	10/PK	EUR 124

Microscope Slide Boxes,25-Place, Red
LC7009-001	GenDepot	EA	EUR 66

Microscope Slide Boxes,25-Place, Red
LC7009-010	GenDepot	10/PK	EUR 124

Microscope Slide Boxes,25-Place, Yellow
LC7010-001	GenDepot	EA	EUR 66

Microscope Slide Boxes,25-Place, Yellow
LC7010-010	GenDepot	10/PK	EUR 124

Microscope Slide Boxes,25-Place, White
LC7011-001	GenDepot	EA	EUR 66

Microscope Slide Boxes,25-Place, White
LC7011-010	GenDepot	10/PK	EUR 124

Microscope slide dispenser for box of 72 standard 25 x 75mm slides
M7100-SD	MTC Bio	1/pack	EUR 69.91
Description: Microscope slide dispenser

FUNNEL, 75 MM, PP
6120P-75	CORNING	12/pk	EUR 40
Description: Reusable Plastics; Reusable Funnels

Proteinase-resistant microscope slides
PO102	FD Neurotechnologies	100 slides	EUR 197

Etoposide (100 mM)
1043-100	Biovision		EUR 153

Microscope slides, positive charged, 45° corners, frosted on one end, 25 x 75mm
M7100-45	MTC Bio	72/pack	EUR 62.83
Description: Microscope slides positive charged

Microscope slides, positive charged, 90° corners, frosted on one end, 25 x 75mm
M7100-90	MTC Bio	72/pack	EUR 62.83
Description: Microscope slides positive charged

Slide dryer attachment for 3 slides
B1000-03	BenchMark	1 PC	EUR 197.97

12 X 75 MM POLYPROPYLENE CULTURE TUBE
T-1275-PP	CORNING	500/pk	EUR 77
Description: Micro Tubes; Screw Cap Macro Tubes - Axygen

12 X 75 MM POLYSTYRENE CULTURE TUBE.
T-1275-PS	CORNING	500/pk	EUR 78
Description: Micro Tubes; Screw Cap Macro Tubes - Axygen

Superfrost® Plus microscope slides
PO103	FD Neurotechnologies	box (72 slides)	EUR 103

ATP Solution (100 mM)
2121-100	Biovision		EUR 126

FUNNEL, 100 MM, PP
6120P-100	CORNING	12/pk	EUR 47
Description: Reusable Plastics; Reusable Funnels

Drying Box, 100 X 40 X 10mm
DB031	Bio Basic	1 UNIT	EUR 76.1

Cardboard freezer box, hinged lid, insert for 25 snap-cap 5ml tubes, 5.25 x 5.25 x 3 inches
C2580-25	MTC Bio	5/pack	EUR 63.37

Nucleotide Set 100mM (4 x 100 mM)
110-010	GeneOn	4 x 100 µl	EUR 56

Nucleotide Set 100mM (4 x 100 mM)
110-011	GeneOn	4 x 200 µl	EUR 68

Slide Rack (for 24 Slides), Stainless Steel
IMS003	ScyTek Laboratories	1 ea.	EUR 96

AXYGEN® 25-WELL COMB FOR USE WITH 10 CM GEL BOX, 1.0 MM THICKNESS
HGB10-25-1	CORNING	1/pk	EUR 59
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 25-WELL COMB FOR USE WITH 10 CM GEL BOX, 2.0 MM THICKNESS
HGB10-25-2	CORNING	1/pk	EUR 59
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 25-WELL COMB FOR USE WITH 20 CM GEL BOX, 1.0 MM THICKNESS
HGB20-25-1	CORNING	1/pk	EUR 69
Description: Lab Equipment; Axygen Branded EQ

100 ML-GLUTAMINE (200 MM, LIQUID)
25-005-CI	CORNING	100 mL/pk	EUR 58
Description: Media Catalog; Cell Culture Reagents

DiagNano Fluorophore Labeled Gold Nanoparticles, 75 nm
GFL-75	Creative Diagnostics	1 mL	EUR 1053

Mini gel tubes, 7 x 2.5 x 75 mm, 8/pk
2394122	Atto	6unit	EUR 263

Cycloheximide (100 mM)
1041-1	Biovision		EUR 142

100 mM CTAB
605	AthenaES	100 ml	EUR 98

dUTP (100 mM)
P033-01	Vazyme	1 ml	EUR 144

dATP (100 mM)
P034-01	Vazyme	1 ml	EUR 144

dTTP (100 mM)
P035-01	Vazyme	1 ml	EUR 144

dCTP (100 mM)
P036-01	Vazyme	1 ml	EUR 144

dGTP (100 mM)
P037-01	Vazyme	1 ml	EUR 144

dCTP 100 mM
FYT014-100UL	Yeastern Biotech	100 µl	Ask for price

Cryo storage box, 100 place (10 x 10), polycarbonate, with hinged lid and unique barcode
R2100	MTC Bio	5/pack	EUR 83.08
Description: Cryo storage box 100 place (10 x 10)

Slide Holder Stainless Steel Rack (for 30 Slides)
IMS005	ScyTek Laboratories	1 ea.	EUR 80

Sodium Pyruvate Solution, 100 mM Solution
CCM1753-100	Bio Basic	100 mL	EUR 60.84

Humid Box for Metal Slide Tray
H011	Insitus Biotechnologies	each	EUR 72

MgCl2 25 mM
BA00154	Bioatlas	5x1.8ml	EUR 62
Description: High purity buffer for various PCR applications.

Mini gel tubes, 7 x 2.5 x 100 mm, 8/pk
2394132	Atto	6unit	EUR 273

Triton® X-100 Detergent
B2394-100	Biovision		EUR 109

Single channel mini-pipette (130 mm) 25 ul, autoclavable
SCMP-25	Alpha Diagnostics	1	EUR 92

38 Place Cold Rack Box
IB002A	Bio Basic	1 UNIT	EUR 63.05

PAS/Glycogen, For Digestion (Control Slides)
TCS0024-25	ScyTek Laboratories	25 Slides	EUR 232

100 mM b-cyclodextrin
609	AthenaES	100 ml	EUR 204

100 mM IPTG Solution
I0356-015	GenDepot	15x1ml	EUR 111

MgCl2 Solution (100 mM)
ABP-PP-ERMGS01	Allele Biotech	1x1ml	Ask for price

MgCl2 Solution (100 mM)
ABP-PP-ERMGS02	Allele Biotech	2x1ml	Ask for price

MgCl2 Solution (100 mM)
ABP-PP-ERMGS05	Allele Biotech	5x1ml	Ask for price

15 LTR SPINNER FLASK, 100 MM CENTRE NECK, 2 X 45 MM SIDEARMS
4500-15L	CORNING	1/pk	EUR 1459
Description: Bioprocess Vessels; Spinner Flask 70

1 LTR SPINNER FLASK, 100 MM CENTRE NECK, 2 X 45 MM SIDEARMS
4500-1L	CORNING	1/pk	EUR 748
Description: Bioprocess Vessels; Spinner Flask 70

36 LTR SPINNER FLASK, 100 MM CENTRE NECK, 2 X 45 MM SIDEARMS
4500-36L	CORNING	1/pk	EUR 2118
Description: Bioprocess Vessels; Spinner Flask 70

3 LTR SPINNER FLASK, 100 MM CENTRE NECK, 2 X 45 MM SIDEARMS
4500-3L	CORNING	1/pk	EUR 842
Description: Bioprocess Vessels; Spinner Flask 70

500 ML SPINNER FLASK, 100 MM CENTRE NECK, 2 X 45 MM SIDEARMS
4500-500	CORNING	1/pk	EUR 529
Description: Bioprocess Vessels; Spinner Flask 70

6 LTR SPINNER FLASK, 100 MM CENTRE NECK, 2 X 45 MM SIDEARMS
4500-6L	CORNING	1/pk	EUR 986
Description: Bioprocess Vessels; Spinner Flask 70

8 LTR SPINNER FLASK, 100 MM CENTRE NECK, 2 X 45 MM SIDEARMS
4500-8L	CORNING	1/pk	EUR 1137
Description: Bioprocess Vessels; Spinner Flask 70

15 LTR SPINNER FLASK, 100 MM CENTRE NECK, 4 X 45 MM SIDEARMS
4510-15L	CORNING	1/pk	EUR 1380
Description: Bioprocess Vessels; Spinner Flask Vertical

36 LTR SPINNER FLASK, 100 MM CENTRE NECK, 6 X 45 MM SIDEARMS
4510-36L	CORNING	1/pk	EUR 2089
Description: Bioprocess Vessels; Spinner Flask Vertical

8 LTR SPINNER FLASK, 100 MM CENTRE NECK, 4 X 45 MM SIDEARMS
4510-8L	CORNING	1/pk	EUR 1137
Description: Bioprocess Vessels; Spinner Flask Vertical

100 ML SODIUM PYRUVATE, LIQUID 100 MM SOLUTION WITH 8.5 G/L NACI
25-000-CI	CORNING	100 mL/pk	EUR 55
Description: Media Catalog; Cell Culture Reagents

20-Place Cardboard Slide Mailer w/Index Sheet
LC7001-010	GenDepot	10/Pk	EUR 151

20-Place Cardboard Slide Mailer w/Index Sheet
LC7001-040	GenDepot	40/CS	EUR 340

TOMO Slides 1 Box
TOMO100	ScyTek Laboratories	100 Slides	EUR 90

COVER GLASS, NO. 1, SQUARE 25 X 25MM
2845-25	CORNING	100/pk	EUR 112
Description: Cover Glass; Cover Glass, CGW

COVER GLASS, NO. 2, SQUARE 25 X 25MM
2855-25	CORNING	50/pk	EUR 86
Description: Cover Glass; Cover Glass, CGW

Human Breast Slide (Normal) (5 slides/pk)
HTS-10001	Alpha Diagnostics	1 pk	EUR 286

Human Breast Slide (Benign) (5 slides/pk)
HTS-10003	Alpha Diagnostics	1 pk	EUR 286

Human Breast Slide (Fibroadenoma) (5 slides/pk)
HTS-10004	Alpha Diagnostics	1 pk	EUR 286

Human Breast Slide (Carcinoma) (5 slides/pk)
HTS-10009	Alpha Diagnostics	1 pk	EUR 286

Human Breast Slide (Abnormal) (5 slides/pk)
HTS-10020	Alpha Diagnostics	1 pk	EUR 286

Human Lung Slide (Normal) (5 slides/pk)
HTS-10101	Alpha Diagnostics	1 pk	EUR 286

Human Lung Slide (Tumor) (5 slides/pk)
HTS-10102	Alpha Diagnostics	1 pk	EUR 286

Human Lung Slide (Adenocarcinoma) (5 slides/pk)
HTS-10106	Alpha Diagnostics	1 pk	EUR 286

Human Lung Slide (Abnormal) (5 slides/pk)
HTS-10110	Alpha Diagnostics	1 pk	EUR 286

Human Liver Slide (Normal) (5 slides/pk)
HTS-10201	Alpha Diagnostics	1 pk	EUR 286

Human Liver Slide (Abnormal) (5 slides/pk)
HTS-10237	Alpha Diagnostics	1 pk	EUR 286

Human Brain Slide (Normal) (5 slides/pk)
HTS-10301	Alpha Diagnostics	1 pk	EUR 286

Human Brain Slide (Tumor) (5 slides/pk)
HTS-10302	Alpha Diagnostics	1 pk	EUR 286

Human Kidney Slide (Normal) (5 slides/pk)
HTS-10401	Alpha Diagnostics	1 pk	EUR 286

Human Kidney Slide (Tumor) (5 slides/pk)
HTS-10402	Alpha Diagnostics	1 pk	EUR 286

Human Kidney Slide (Abnormal) (5 slides/pk)
HTS-10455	Alpha Diagnostics	1 pk	EUR 286

Human Heart Slide (Normal) (5 slides/pk)
HTS-10501	Alpha Diagnostics	1 pk	EUR 286

Human Heart Slide (Tumor) (5 slides/pk)
HTS-10502	Alpha Diagnostics	1 pk	EUR 286

Human Heart Slide (Myxoma) (5 slides/pk)
HTS-10503	Alpha Diagnostics	1 pk	EUR 286

Human Heart Slide (Abnormal) (5 slides/pk)
HTS-10525	Alpha Diagnostics	1 pk	EUR 286

Human Colorectal Slide (Normal) (5 slides/pk)
HTS-10701	Alpha Diagnostics	1 pk	EUR 286

Human Colorectal Slide (Benign) (5 slides/pk)
HTS-10702	Alpha Diagnostics	1 pk	EUR 286

Human Colorectal Slide (Adenocarcinoma) (5 slides/pk)
HTS-10704	Alpha Diagnostics	1 pk	EUR 286

Human Cervix Slide (Normal) (5 slides/pk)
HTS-11301	Alpha Diagnostics	1 pk	EUR 286

Human Cervix Slide (Benign) (5 slides/pk)
HTS-11303	Alpha Diagnostics	1 pk	EUR 286

Human Cervix Slide (Abnormal) (5 slides/pk)
HTS-11316	Alpha Diagnostics	1 pk	EUR 286

Human Bladder Slide (Normal) (5 slides/pk)
HTS-12601	Alpha Diagnostics	1 pk	EUR 286

Human Melanoma Tissue Slide (5 slides/pk)
HTS-12801	Alpha Diagnostics	1 pk	EUR 286

Human Cartilage Slide (Benign) (5 slides/pk)
HTS-12903	Alpha Diagnostics	1 pk	EUR 286

Human Bone Slide (Chondrosarcoma) (5 slides/pk)
HTS-12907	Alpha Diagnostics	1 pk	EUR 286

Triton X-100
abx082488-100ml	Abbexa	100 ml	EUR 175

Triton X-100
abx082515-100ml	Abbexa	100 ml	EUR 189

Triton X-100
TB0198	Bio Basic	500ml	EUR 65.08

Triton X-100
GD6826-100ML	Glentham Life Sciences	100 ml	EUR 44

Triton X-100
GD6826-1L	Glentham Life Sciences	1 l	EUR 62

Triton X-100
GD6826-250ML	Glentham Life Sciences	250 ml	EUR 52

Triton X-100
GD6826-500ML	Glentham Life Sciences	500 ml	EUR 55

Triton X-100
GD6826-5L	Glentham Life Sciences	5 l	EUR 142

2947 75 X 25MM
2947-75X25	CORNING	0,5/pk	EUR 248
Description: Slides; Slides

2947 75 X 38MM
2947-75X38	CORNING	0,5/pk	EUR 209
Description: Slides; Slides

2947 75 X 50MM
2947-75X50	CORNING	0,5/pk	EUR 265
Description: Slides; Slides

2948 75 X 25MM
2948-75X25	CORNING	0,5/pk	EUR 317
Description: Slides; Slides

2949 75 X 25MM
2949-75X25	CORNING	0,5/pk	EUR 405
Description: Slides; Slides

CA Syringe Filter, 0.22 µm, 25 mm, Nonsterile
M4219-100	Biovision		EUR 294

CA Syringe Filter, 0.22 µm, 25 mm, Nonsterile
M4220-100	Biovision		EUR 320

CA Syringe Filter, 0.45 µm, 25 mm, Nonsterile
M4224-100	Biovision		EUR 294

CA Syringe Filter, 0.45 µm, 25 mm, Nonsterile
M4225-100	Biovision		EUR 294

CA Syringe Filter, 0.45 µm, 25 mm, Nonsterile
M4226-100	Biovision		EUR 294

CA Syringe Filter, 1 µm, 25 mm, Nonsterile
M4229-100	Biovision		EUR 294

CA Syringe Filter, 3 µm, 25 mm, Nonsterile
M4231-100	Biovision		EUR 294

CA Syringe Filter, 5 µm, 25 mm, Nonsterile
M4234-100	Biovision		EUR 294

Glass Fiber Syringe Filter, 0.22 µm, 25 mm
M4238-100	Biovision		EUR 294

Glass Fiber Syringe Filter, 0.45 µm, 25 mm
M4240-100	Biovision		EUR 294

Glass Fiber Syringe Filter, 0.70 µm, 25 mm
M4242-100	Biovision		EUR 294

Glass Fiber Syringe Filter, 1 µm, 25 mm
M4244-100	Biovision		EUR 294

Glass Fiber Syringe Filter, 1.0 µm, 25 mm
M4246-100	Biovision		EUR 376

Glass Fiber Syringe Filter, 5 µm, 25 mm
M4247-100	Biovision		EUR 294

Glass Fiber Syringe Filter, 10 µm, 25 mm
M4248-100	Biovision		EUR 294

Nylon Syringe Filter, 0.10 µm, 25 mm, Nonsterile
M4269-100	Biovision		EUR 294

Nylon Syringe Filter, 0.22 µm, 25 mm, Nonsterile
M4274-100	Biovision		EUR 294

Nylon Syringe Filter, 0.22 µm, 25 mm, Nonsterile
M4275-100	Biovision		EUR 294

Nylon Syringe Filter, 0.22 µm, 25 mm, Nonsterile
M4277-100	Biovision		EUR 376

Nylon Syringe Filter, 0.45 µm, 25 mm, Nonsterile
M4282-100	Biovision		EUR 376

Nylon Syringe Filter, 0.45 µm, 25 mm, Nonsterile
M4283-100	Biovision		EUR 294

Nylon Syringe Filter, 0.45 µm, 25 mm, Nonsterile
M4284-100	Biovision		EUR 294

Nylon Syringe Filter, 0.45 µm, 25 mm, Nonsterile
M4285-100	Biovision		EUR 316

Nylon Syringe Filter, 1 µm, 25 mm, Nonsterile
M4289-100	Biovision		EUR 294

Nylon Syringe Filter, 1 µm, 25 mm, Nonsterile
M4290-100	Biovision		EUR 294

Nylon Syringe Filter, 3 µm, 25 mm, Nonsterile
M4293-100	Biovision		EUR 316

Nylon Syringe Filters, 3 µm, 25 mm, Nonsterile
M4294-100	Biovision		EUR 294

Nylon Syringe Filters, 5 µm, 25 mm, Nonsterile
M4297-100	Biovision		EUR 294

Nylon Syringe Filters, 5 µm, 25 mm, Nonsterile
M4298-100	Biovision		EUR 294

Nylon Syringe Filters, 10 µm, 25 mm, Nonsterile
M4299-100	Biovision		EUR 294

Slide labeled and dated in handwriting Boveri and thus can be assigned to publish the experimental work at sea urchin development. Results Boveri allowed to reveal the role of the cell nucleus and chromosomes in the development and heritage. Here, I present an overview of the slides in the context Boveri work together with images of selected specimens taken from the original slide. It is planned to check the slide in more detail, taking high-resolution pictures a series of specimens of significant focus and make them available online.